SURVEYING INSULIN RESISTANCE IN SUBJECTS WITH PREDIABETES DETECTED FOR THE FIRST TIME

Abstract

Pre-diabetes is a limited hyperglycemia and a direct risk of type 2 diabetes. To prevent the progression of diabetes, it is necessary to assess insulin resistance and its association with some clinical features of first detected prediabetes. The study was conducted on 117 pre-diabetes people, who were diagnosed according to the standards of the Vietnam Endocrinology - Diabetes Association. Insulin resistance is based on the HOMA2 formula with normal value glucose-insulin pair. Insulin resistance indexes are based on the corresponding reference in the normal person. The results showed that the rate of insulin resistance (HOMA2-IR) was 72.6%, decreased insulin sensitivity (HOMA2-%S) was 53.8% and decreased beta cell function (HOMA2-b) was 37.6%. The insulin resistance index (HOMA2-IR) increases with age, obesity, lipid disorders, but not related to gender, waist circumference, hypertension and metabolic syndrome.