CAR-NK RESEARCH - A PROMISING DIRECTION OF IMMUNE THERAPIES AGAINST CANCER

Abstract

Today, scientists are always trying to find valuable applications new methods based on free in-body service providers. NK is a very important component of the immune system, we can kill cancer cells without induction. However, cancer cells use a variety of tactics to experiment, creating the immune system's failure to block the application. So, they used gene editing technology to introduce CAR - a beneficiary material into NK, which enhances the anti-tumor activity of NK. The objective of this paper is to provide information on the structure of CAR, commonly used NK sources, and methods of CAR conversion and activation in NK to create a complete CAR-NK. The research method of the article is a synthesis of articles on CAR-NK generation methods. The results we obtained are as follows: CAR has a structure of 3 regions, commonly used NK sources are NK92 and PBMC lines; there are two ways to transfer CAR into NK: viral loading and transduction; user to be used to active CAR in NK to CAR-NK has a stronger anti-tumor effect. Clinical application of CAR-NK will become a promising weapon in the fight against cancer.