ASSOCIATION OF SOX5 rs10842262 WITH MALE INFERTILITY IN 325 VIETNAMESE INDIVIDUALS

Abstract

Male infertility is becoming increasingly prevalent. Numerous studies demonstrated the association of single nucleotide polymorphisms and increasing male infertility. To assess the relationship between SOX5 rs10842262 and the risk of male infertility in Vietnamese population, 140 male infertility patients diagnosed with non-obstructive azoospermia or oligozoospermia and 185 healthy controls were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Statistical analysis demonstrated that the allele frequencies of SOX5 rs10842262 followed Hardy-Weinberg equilibrium (HWE) (p-value > 0.05). The Chi-square test revealed no correlation between the polymorphism and male infertility in this study (p-value > 0.05). Our finding was the first study on the  association between single nucleotide polymorphism in SOX5 gene and male infertility in the Vietnamese population. To confirm the results on the association of SOX5 rs10842262 and male infertility in the Vietnamese population, further studies with larger sample size should be conducted.