THE CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF STEM EXTRACTS OF Adinandra glischroloma

Abstract

Adinandra glischroloma collected in Lao Cai province, Vietnam belongs to Adinandra genus. Some species of the Adinandra genus have been studied for their botanical characteristics and bioactive compounds, however, A. glischroloma has not been studied to date.Therefore, studying the chemical composition and biological activity of A. glischroloma stem extracts is necessary. The stem extracts of A. glischroloma have been quantified and determined whether they contain flavonoids, coumarins and polyphenolic compounds. The stem extracts were not able to inhibit the growth of the test bacteria (except, the dichloromethane extract inhibited B. subtilis and L. plantarum at a concentration of 200 µg/mL). The dichloromethane extract, ethyl acetate extract and ethanol extract have free radical reduction activity, which EC₅₀ values ​​reached 86.7, 88.5, and 111.2 µg/mL, respectively. The ethanol extract exhibited inhibitory activities on breast cancer, lung and gastric cell lines with IC₅₀ values ​​of 59.1, 63.23, and 67.48 µg/mL, respectively. The results show that A. glischroloma is a potential plant that contains many compounds that have biological activities that need to be further researched and exploited.