IN VITRO ANTIBACTERIAL ACTIVITY OF AMPELOPSIS CANTONIENSIS EXTRACTS CULTIVATED AT DANANG AGAINST CLINICALLY ISOLATED STAPHYLOCOCCUS AUREUS

Abstract

The Gram-positive Staphylococcus aureus is a common pathogen that causes many serious infectious diseases in humans, especially in hospital settings. Therefore, discovery and development of new antibiotics or new generations of antibiotics to treat infections caused by S. aureus is an urgent issue in Vietnam and all over the world. In this study, we isolated S. aureus from patient sample and investigated the antibacterial potency of Ampelopsis cantoniensis extracts collected in Da Nang. The results showed that ethanolic crude extract can suppress in vitro growth of this strain after 24 hours. The ethylacetate fraction has the highest inhibitory effect on the growth of S.aureus bacteria, with minimum inhibitory concentration (MIC) of 0,1 mg/ml and minimum bactericidal concentration (MBC) of 0,4 mg/ml. Whereas, extract of n-hexane fraction does not show antibacterial activity against S. aureus. These initial results are the premise for further studies on the antibacterial mechanism of Ampelopsis cantoniensis in the future.