Antibiotic resistance of some gram-negative bacteria at Hai Phong International General Hospital from 2020 to 2024

Abstract

This study investigates the antibiotic resistance of Gram-negative bacteria at Hai Phong International General Hospital from January 2020 to October 2024. A retrospective analysis was conducted on microbiological test data collected during this period, focusing on the isolation rates and resistance profiles of key bacteria such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Escherichia coli. The results indicated a total of 363 samples analyzed, with Pseudomonas aeruginosa having the highest isolation rate from urine samples (24.24%), followed by sputum (17.36%). Antibiotic resistance analysis revealed resistance rates of 55.56% for Ampicillin-Sulbactam and 50% for Amikacin. Other antibiotics such as Ertapenem (28.82%), Cefepime (28.13%), and Moxifloxacin (30.61%) also exhibited high resistance rates. Acinetobacter baumannii was primarily isolated with a total of 98 samples, where samples from bronchial secretions accounted for 23.47% and urine (17.35%). Doxycycline showed the highest resistance rate (90.63%), followed by Tetracycline (77.14%). Although no resistant strains of Meropenem were found, other carbapenems like Ertapenem and Imipenem exhibited significant resistance rates (50% and 53.13%, respectively). Escherichia coli was isolated positively from 2,436 samples, with an ESBL rate of 26.03%. The majority of Escherichia coli was isolated from urine samples (73.11%). Resistance rates of Escherichia coli to Ciprofloxacin and Moxifloxacin were 50% and 49.65%, respectively. These findings underscore the necessity for continuous monitoring and implementation of antibiotic stewardship programs to address the increasing threat of antibiotic resistance among Gram-negative bacteria in the hospital environment.