Clinical and laboratory features and results of treatment of children with dengue hemorrhagic fever at Hai Phong Medical University Hospital in 2023 - 2024

Abstract

Objectives: To review clinical and paraclinical characteristics, some factors related to the severity of dengue fever and the treatment results of dengue fever at the Department of Pediatrics, Hai Phong University of Medicine and Pharmacy Hospital in 2023-2024. Study subjects: 275 children under 16 years old were diagnosed with dengue fever based on clinical and paraclinical criteria according to the guidelines of the Ministry of Health in 2023. Study period: August 1, 2023 to July 31, 2024. Method: Describe a series of cases using retrospective data. Results: Dengue fever begins to appear in the summer months, peaks in the fall, and gradually decreases in the winter months. Common clinical symptoms were: fever occurs in 100%, subcutaneous hemorrhage (87.64%), nausea, vomiting (87.27%); muscle pain, joint pain, pain in both eye sockets (89.36%). Disease severity: Dengue fever (11.64%), Dengue fever with warning signs (87.64%), Severe Dengue fever (0.73%). The rate of patients with NS1-Ag antigen test (+) was 92%. Hematocrit index, AST, ALT enzyme activities in the group of Dengue fever patients with warning signs were much higher than in the group of Dengue fever patients with p<0.05; the number of platelets, white blood cells in the group of Dengue fever patients with warning signs was lower than in the group of Dengue fever patients (p<0.05). Treatment results: 274/275 patients were cured (99.63%), 1 patient was referred to a higher hospital and no patients died. Conclusion: Dengue fever with warning signs accounted for the highest rate of 87.64%. There was a correlation between increased hematocrit index, increased AST, ALT enzymes and decreased platelet count in the Dengue fever group compared to the Dengue fever group with warning signs (p< 0.05). The rate of patients cured was 99.63%.