Cardiovascular abnormalities in fetus with DiGeorge syndrome detected by ultrasound at the National Hospital of Obstetrics and Gynecology

Abstract

Objectives: Describe the characteristics of pregnant women with DiGeorge syndrome (DGS). Describe the cardiovascular abnormalities in DiGeorge syndrome detected by ultrasound. Research method: Descriptive research of a series diseases. Results: 23/31 pregnant women with DGS who indicated for amniocentesis were under the age of 35, nearly 3 times higher than the group of pregnant women over the age of 35 (8 pregnant women corresponded to 25.8%). Statistics of cardiovascular abnormalities seen in DiGeorge syndrome with the overall rate is 64.5%. In which tetralogy of Fallot was the most common with 15 cases, accounting for 48.4%; followed ventricular septal defect (4 cases with 12.9%) and vascular abnormalities (1 case with 3.2%). The time of abnormal detection of tetralogy of Fallot in fetus with DiGeorge syndrome is quite late, most cases are detected at 20-24 weeks of gestation (9 cases - 60%). With 4 cases of ventricular septal defect, the fetus was detected at the earliest at 17 weeks and 6 days of ultrasound, 24 weeks and 4 days at the latest. Vascular abnormalities were detected at 22 weeks of pregnancy (left ventricular outflow tract stenosis), aortic arch dilatation. Conclusion: There is no relationship between increased incidence of DiGeorge syndrome pregnancy according to maternal age. Cardiovascular abnormalities are common abnormalities in DiGeorge syndrome with 64.5% (20/31 cases), in which tetralogy of Fallot is most specific for DGS with 15 cases accounting for 48.4%, followed by tetralogy of Fallot. 4 cases of ventricular septal defect (12.9%), 1 case of abnormal pulse accounted for 3.2%. The time to detect cardiovascular abnormalities is quite late, usually at weeks 20-22.