Culture of EV71 virus in wave bioreactor system for production of hand, foot and mouth disease vaccine

  • Thi Yen Nhi Nguyen, Thi Hanh Lan Nguyen, Ngoc Khanh Quynh Hoang, Thi Lien Le, Ha Tam Duong Le, Thi Bao Van Cao
  • Thi Yen Nhi Nguyen
  • Thi Bao Van Cao*
Keywords: Cytodex 1, EV71, HFM vaccine, Vero cell, Wave bioreactor.

Abstract

The study was carried out to establish an EV71 virus culture system on Vero cells in a shake culture system (Wave bioreactor) incorporating microcarriers for
the production of hand, foot and mouth (HFM) vaccine caused by the EV71 virus. The results of the investigation of 2 types of microcarriers (Cytodex 1 and
Cytodex 3), showed that Cytodex 1 gave better efficiency when culturing Vero cells in suspension conditions...

Tác giả

Thi Yen Nhi Nguyen, Thi Hanh Lan Nguyen, Ngoc Khanh Quynh Hoang, Thi Lien Le, Ha Tam Duong Le, Thi Bao Van Cao

Pasteur Institute in Ho Chi Minh city

Thi Yen Nhi Nguyen

University of Science, Vietnam National University, Ho Chi Minh city

Thi Bao Van Cao*

Vancao Medipharm Technology Institute

điểm /   đánh giá
Published
2022-09-22
Issue
Vol. 64 No. 9B (2022): Tập 64 - Số 9 - Tháng 9 - năm 2022
Section
KHOA HỌC Y - DƯỢC