Evaluating the effect of screening dual HLA-A*31:01 and HLA-B*15:02 alleles by multiplex real-time PCR technique on reducing the risk of Carbamazepine-induced hypersensitivity reactions

  • Thi Ngoc Hao Vo1, Van Son Chu, Thi Van Anh Nguyen*
  • Doan Thuy Nguyen, Van Lieu Nguyen
  • Van Lieu Nguyen
Keywords: Carbamazepine, HLA-A*31:01, HLA-B*15:02, multiplex real-time PCR, severe cutaneous adverse reactions (SCARs)

Abstract

Human leukocyte antigen (HLA) gene polymorphisms HLA-A*31:01 and HLA-B*15:02 are strongly associated with Carbamazepine (CBZ)-induced severe cutaneous adverse reactions (SCARs). As a result, it is recommended to screen these two alleles before CBZ therapy to reduce the risk of drug allergy...

Tác giả

Thi Ngoc Hao Vo1, Van Son Chu, Thi Van Anh Nguyen*

Key Laboratory of Enzyme and Protein Technology,
University of Science, Vietnam National University, Hanoi

Doan Thuy Nguyen, Van Lieu Nguyen

Neurology and Stroke Department, Tam Anh General Hospital

Van Lieu Nguyen

Department of Neurology, Hanoi Medical University

điểm /   đánh giá
Published
2023-05-18
Issue
Vol. 65 No. 5B (2023): Volume 65 - Number 5 - May 2023
Section
KHOA HỌC Y - DƯỢC