Nghiên cứu đặc tính và đánh giá tiềm năng bảo vệ thần kinh của Vitexin tách chiết từ vỏ đỗ xanh (Vigna radiata L)

Abstract

Vitexin is a flavonoid of significant therapeutic interest, found in plants such as mung bean, and is recognized for its potent antioxidant, hypoglycemic and neuroprotective effects. In this study, we presented the successful optimization and implementation of a vitexin extraction process from mung bean coats. The procedure was conducted at a 10 kg raw material per batch scale, utilizing 80% ethanol solvent at a raw material-to-solvent ratio of 1:3 (w/v). The extracted vitexin achieved a purity of 91.73% and an extraction efficiency of 0.231%. The isolated vitexin exhibited significant biological activities, including potent antioxidant activity (IC50 of 226.06 ± 11.3 ppm) and AChE inhibitory activity (IC50 of 150.90 ± 4.5 ppm). Furthermore, it demonstrated cytoprotective activity against Aβ25-35-induced toxicity. The obtained results indicated that vitexin isolated from mung bean coats meets the necessary standards for the fabrication of nanovitexin, thereby enhancing its absorption and biological activity, serving as a raw material for producing functional of foods that support the prevention and treatment of chronic diseases.