SYNTHESIS OF QUINOLIZINE - CHALCONE DERIVATIVES

Abstract

The novel compound 2-(3-(4-methoxybenzoyl)oxiran-2-yl)-4H-quinolizin-4-one was successfully synthesized through a Stobbe-type condensation/cyclization sequence, starting from 2- pyridinecarbaldehyde under strong base conditions with potassium tert-butylate as catalyst. The synthetic procedure was optimized and afforded the product in relatively high yield. The chemical structure of the compound was confirmed by modern spectroscopic techniques, including MS, ¹H-NMR, ¹³C-NMR, COSY, DEPT, HMBC, and HSQC. These results demonstrate the feasibility of the synthetic approach and open up prospects for the development of new derivatives bearing the quinolizinoneepoxide scaffold with potential applications in pharmacological research.