Study on preparation of solid dispersion system for of nifedipine by spray drying technique

Abstract

To enhance the dissolution rate of nifedipine, a solid dispersion system (SDs) was formulated and prepared by drying spray technique. The carriers in SDs being investigated were PEG 6000, PVP K30, Poloxamer and mannitol. Effects of these carriers in SDs were evaluated each alone or and in their combinations. The optimal formulum of choice (CT14) achieved an drying spray yield of 62.5 %; nifedipine release attained approximately 100 % after 20 mins; nifedipine solubility from CT14-SDs increased significantly comparing with material nifedipine. The other properties of the CT14-SDs was evaluated by X-ray diffraction (XDR) and scanning electron microscopy (SEM). The amorphous state of nifedipine in SDs was confirmed by XDR. Whereas, by SEM pictures, the SDs particles were estimated in good spherical shape with mean size of 5 µm, i.e. changes in surface nature of nifedipine were well-defined, Furthermore, CT14-SDs was layered on the inner core pellets (sugar cores) with a fluid bed coater. The prepared NF pellets demonstrated high dissolution rate (NF release > 80 % after 20 min and > 90 % of after 60 min).