Study on formulation of nanoemulsions of curcumin with cyclodextrin as oral delivery

Abstract

 Nanoemulsions for curcumin were formulated and stabilised by β-cyclodextrin (β-CD). Curcumin was encapsulated in oil droplets of nanoemulsion using Tween 80 as surfactant and β-CD as stabilizing agent. The obtained nanoemulsions were characterized for droplet size, size distribution, in vitro release and physical stability. The most suitable formulation of choice was composed of vegetable oil 10 %, Tween 80 1.5 % and β-CD 3.0 % (w/v). The mean droplet diameter and polydispersity index of the obtained curcumin nanoemulsions were 317.2 ± 0.8 nm and 0.274 ± 0.008, respectively. The drug release in vitro of curcumin was 70.28 % in 24 hrs. Physically, curcumin nanoemulsions with 3.0 % β-CD w/v were well stable after 4 weeks of storage, whereas those free of β-CD proved evident unstability just after 1 week.