Synthesis, and antimicrobial, antifungal activity of some 5-nitrobenzimidazol-2-thione derivatives

Abstract

Presently, there are more and more strains of bacteria which against antibiotics. So, we should have professional reseach in order to find new drugs which have better potential antibacterial and antifugal activities. As antibiotics resistance is increasing, in hơp of creating potential antibiotics, nine new compounds (1-9) were synthesized from 5-nitrobenzimidazole-2-thione and further screened for antibacterial and antifungal activity.  The synthesized compounds were characterized by melting point, thin layer chromatochraphy (TLC), structural elucidation by UV, IR, ¹H-NMR, ¹³C-NMR and MS. Their antibacterial and antifungal activity were different one from another derivative. While two strains of P. aeuroginosa and S. faecalis were not inhibited by tested compounds, 4/9 derivatives (substances 1, 3, 6 and 7) inhibited E. coli and 6/9 derivatives (substances 1, 3, 5, 6, 7 and 8) inhibited methicillin-resistant Staphylococcus aureus (MRSA). For antifulgal activity, Candida albicans were inhibited by 6/9 derivatives (1, 3, 5, 6, 7, 8). For inhibitivity against T. rubrum, T. mentagrophytes, M. gypseum, the MIC of the 3 substances 5, 7 and 8 were significant.