Relation between T1 and T2 mapping with wall thickness and late gadolinium enhancement of myocardial segments in patients with hypertrophic cardiomyopathy on 3 Tesla magnetic resonance imaging

Abstract

Objective: To investigate T1 and T2 mapping values of local myocardial segments on 3 Tesla Magnetic Resonance Imaging, in patients with hypertrophic cardiomyopathy (HCM).
Methods: A prospective- cross-sectional descriptive study recruited 22 patients diagnosed with HCM who underwent 3T Magnetic Resonance at Bach Mai Hospital from 08/2023 to 08/2024.
Results: 68% men, mean age was 50.55 ± 18.79 years. Native T1 values increased in non-hypertrophic, mild, moderate, and severe hypertrophic segments, with the mean values are 1215.17 ± 33.01 ms, 1281.69 ± 15.48ms, 1332.07 ± 11.24 ms and 1378.71 ± 16.74 ms respectively. The mean native T1 values of myocardial segments with LGE were significantly higher than those without LGE, with p < 0.001. The average T2 value increased in the moderate and severe hypertrophy
segments with mean values are 49.76 ± 5.30 ms and 48.13 ± 9.80 ms, respectively. Of a total of 352 myocardial segments, 50 segments (14.2%) had late gadolinium enhancement (LGE).
Conclusions: Native T1 and T2 mapping values can provide additional value for HCM diagnosis at an early stage.