THE ROLE OF FMS-RELATED RECEPTOR TYROSINE KINASE 3 (FLT3) IN THE PATHOGENESIS OF ACUTE MYELOGENOUS LEUKEMIA

  • Nguyễn Trung Quân
  • Hoàng Thành Chí

Abstract

FMS-like tyrosine kinase 3 (FLT3) is almost exclusively expressed on hematopoietic stem cells and is essential for their survival, proliferation, and development. Acute myeloid leukaemia (AML) may be caused by abnormalities associated with overexpression of the FLT3 protein or mutations in the FLT3 gene, which are frequently associated with a poor prognosis. In addition, some FLT3-targeted therapies, research, and clinical applications are updated.

điểm /   đánh giá
Published
2023-06-15
Issue
No. 3(64) (2023)
Section
Bài viết