ANTIOXIDANT AND INHIBITIVE CAPACITY IN HEPG2 AND HCC-J5 LIVER CANCER CELLS OF METHANOL EXTRACT FROM ANDROGRAPHIS PANICULATA (BURM. F.) LEAVES COLLECTED IN AN GIANG

Abstract

Andrographis paniculata is a popular medicinal herb in several traditional remedies to treat human illnesses. Scientific research in recent years has provided solid evidence of the remarkable properties of this medicinal plant, including its antioxidant, anti-inflammatory, and antibacterial effects, its ability to suppress the development of cancer cells, and, notably, its effectiveness in treating COVID-19. Nevertheless, the efficacy of A. paniculata in the treatment of liver-related disease has not been well documented. The antioxidant activity and anti-hepatocarcinoma capacity of the crude extract from Androg zaphis paniculata leaves collected in An Giang were measured using the DPPH testing method and cytotoxicity assessment with MTT dye. The findings indicated that the extract exhibited low antioxidant activity and potent inhibitory action against the growth of HCC-J5 and HepG2 liver cancer cells, with IC50 values of 46.80 ± 3.03µg/mL and 34.24 ± 4.67µg/mL, respectively.