NGHIÊN CỨU TỔNG HỢP TIỀN CHẤT 2-METHYL-1H-IMIDAZOLE ĐỂ SẢN XUẤT THUỐC KHÁNG SINH METRONIDAZOLE

Abstract

2-Methyl-1H-imidazole precursor is used to synthesize the antibiotic Metronidazole, which is highly effective against anaerobic bacteria. Metronidazole has been employed as a drug to treat infections caused by bacteria such as Trichomonas, amoebic bacteria, and Helicobacter pylori (HP) bacteria that cause peptic ulcer disease and also pose a risk of leading to stomach cancer. To synthesize the 2-methyl-1Himidazole precursor, the research group identified factors affecting the synthesis process such as: Temperature in the range of 210-220°C; Ethylenediamine/acetic acid ratio of 1/3, and crystallization using ethyl acetate solvent, achieving a synthesis efficiency of 95%. This paper is the result of research on the synthesis of the 2-methyl- 1H-imidazole precursor for the production of the antibiotic Metronidazole. The research results provide a scientific basis for the practical application of production technology processes, with the aim of contributing to the self-sufficient development of pharmaceutical raw materials in Vietnam."