ISOLATION OF COMPOUNDS FROM COPTIS CHINENSIS ROOTS
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DOI:
https://doi.org/10.34238/tnu-jst.12611Abstract
Coptis chinensis Franch., a species belonging to the genus Coptis in the family Ranunculaceae, is a rare medicinal plant renowned for its high pharmaceutical value. It is particularly rich in alkaloids, which are recognized as its principal bioactive constituents. These compounds exhibit a wide range of pharmacological activities, including anti-inflammatory, antitumor, antibacterial, antifungal, antidiabetic, and anti-Alzheimer's activities. In this study, compounds were isolated and characterized from the rhizome of C. chinensis using column chromatography, thin-layer chromatography, semi-preparative high-performance liquid chromatography, and nuclear magnetic resonance spectroscopy. As a result, five compounds were successfully isolated, including three alkaloids- noroxyhydrastine (1), berberine (2), and jatrorrhizine (3); and two non-alkaloid compounds - p-coumaric acid (4), a phenolic acid, and vomifoliol (5), an apocarotenoid. These findings contribute to the phytochemical profile of C. chinensis and enhance the current understanding of alkaloid-rich plant species in Vietnam, particularly within the Coptis genus.Downloads
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