PLASMA CHOLINESTERASE ENZYME ACTIVITY IN CIRRHOSIS IN BAC KAN GENERAL HOSPITAL

Abstract

This study aims to evaluate plasma cholinesterase enzyme activity and some biochemistry test in cirrhosis in Bac Kan General Hospital. A cross study was carried out on 113 cirrhosis patients in Bac Kan General Hospital from August 2019 to June 2020. The results show that among 113 studied patients, the majority were males (92.9%) in the age group of 40 to 49 years (49.6%). The most common aetiological factor in this study was alcohol (75.2%). Some clinical signs included ascites (53.1%), icterus (86.7%), splenomegaly (43.4%) and hepatic encephalopathy (4.4%). The patients were mostly in Child Pugh class B (46.9%). The mean of plasma CHE in cases and controls were 4157±2567 U/L and 9248±2070 U/L respectively. On analysing the correlation between serum cholinesterase and other liver function tests, it was found that there was significant correlation with albumin, bilirubin, INR levels, Child Pugh. Plasma cholinesterase activity tended to significantly decrease in cirrhosis. A significant correlation was found between plasma cholinesterase levels and the severity of Cirrhosis.