CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITIES OF CURCULIGO ORCHIOIDES GROWING IN TUYEN QUANG PROVINCE

Abstract

The article describes the qualitative analysis, quantitative analysis, evaluating antimicrobial activity, antioxidant activity of extracts from SC using the method of high pressure liquid chromatography (HPLC), method of Bertrand, Levanthal, Vietnamese Pharmacopoeia 4, the in vitro anti-microbial activity was evaluated by Minimum Inhibitor Concentration (MIC) method, in vitro antioxidant activity by DPPH. The results of the study showed that Curculigo orchioides medicinal herbs contain several classes of chemicals such as: saponins, phytosterols, flanonoids, free reducing sugars, fats, alkaloids, carotene, tannins and organic acids. Free reducing sugar (10.7%), starch (35.3%), cellulose (15.1%), ash (6.9%), moisture (9.1%), tannins (3.6%), saponins (19.8%), phytosterols (23.1%), flavonoids (4.3%), and alkaloids (0.9%). The fraction exhibited (CO) displayed moderate activity against Escherichia coli, Bacillus subtillis, Fusarium oxysporum và Candida albicans with MIC 200 µg/ml, the COE against Escherichia coli, Aspergillus niger và Fusarium oxysporum with MIC 200 µg/ml, significant activity against Bacillus subtillis with MIC 100 µg/ml. The ethyl acetate (COE, CO) fraction exhibited with respective SC₅₀ of 36.85; 43.22 µg/ml and COW with SC₅₀ of 90.54 µg/ml.