Alpha-glucosidase inhibitory activity and chemical constituents of Satholobus parviflorus (roxb.)

Abstract

     Our preliminary screening study revealed that the methanolic extract of Stholobus parviflorus (Roxb.) exhibited potent a-glucosidase inhibitory activity with an IC₅₀ value of 0.05 μg mL^-1. Therefore, we carried out activity-guided fractionation of the MeOH extract and isolated three compounds. These compounds were determinated as ferulic acid (1), protocatechuic acid (2) and epicatechin (3) by analysis of spectroscopic data. The IC₅₀ values of these compounds were 45.30, 23.04 and > 100 μM, respectively. Acid tannic was used as a positive control with an IC₅₀ value of 0.91 nM.