Study on phytochemical composition and acute toxicity of leaf extract from Artocarpus altilis Moraceae

Abstract

In Viet Nam, the leaves of breadfruit trees have many pharmacological effects in traditional medicine such as: curing diabetes, gout, atherosclerosis, anti-anxiety, etc. The study was conducted on the purpose of phytochemical screening and acute toxicity of extracts from Artocarpus altilis Moraceae. Materials and Methods: Materials: Leaves of Artocarpus altilis were collected at Ninh Thuan province. Methods: The leaves were extracted via hot extraction method. Identification of the chemical constituents of the herb was carried out using Ciuley method. Acute toxicity is determined via the method of Do Trung Dam [8]. Results: Identified compounds in extracts: Flavonoids, triterpenoids, polyphenols, and polyuronic compounds. The extract has not shown toxicity in rats with D_max (166.040 g/kg). Conclusion: The leaves and extract from Artocarpus altilis Moraceae have phytochemicals include: Flavonoid, triterpenoid, polyphenol, polyuronic compounds. It has not shown toxicity in test mice with Dmax dose (166.040 g/kg).