NGHIÊN CỨU THÀNH PHẦN HOÁ HỌC VÀ HOẠT TÍNH KHÁNG NẤM CỦA CỦ CÂY ĐẢNG SÂM CODONOPSIS PILOSULA

Tóm tắt

Codonopsis pilosula (Franch.) Nannf., a plant of the Campanulaceae family, is a well-known traditional medicinal material. Until now there are few of reports on the chemical composition and phamarcological activity of this plant. This paper reports on the process of extracting and determining the total saponin and polysaccharide contents of the roots of C. pilosula growing in Quang Nam
province. Using chromatographic methods, we successfully isolated the principal lobetyolin. Its chemical structure was determined by mass fragmentation analysis of ESI-MS/MS data and comparision with those in the literatures. The total saponin content is more than 3% and polysaccharide is more than 9%. These contents were relatively high, proving that the chemical
composition was related to the pharmacological effects of C. pilosula. Bioassay for antifungal activity of n-butanol extracts from C. pilosula was carried out by food-poisoned technique. These n-butanol extracts were consistently effective toward Sclerotium rolfsii and showed a weak inhibition against Fusarium oxysporum