NGHIÊN CỨU KẾT HỢP HẠT NANO VÀNG VỚI APTAMER ĐẶC HIỆU XÁC ĐỊNH MỘT SỐ CHẤT DẪN TRUYỀN THẦN KINH

Abstract

The accurate detection and quantification of Dopamine and Serotonin, two crucial neurotransmitters, play
an essential role in understanding and treating a range of mental and neurological disorders. This research
focused on the development of a novel method for the precise and straightforward identification of
Dopamine and Serotonin, by integrating specific aptamers with gold nanoparticles (AuNPs). With the
optimal conditions that were investigated, the standard curve for determining Dopamine and Serotonin was
constructed with a high correlation coefficient (> 0.99), and the limits of detection (LOD) for Dopamine and
Serotonin were 1.7 nM and 1.4 nM, respectively. Simultaneously, the selectivity of the method was evaluated
in the presence of various interfering substances. The results indicated a relatively high selectivity of the
method when interfering substances were present. These findings not only provided a robust foundation for
the development of rapid, accurate, and sensitive analytical methods for Dopamine and Serotonin but also
opened up new research directions in the field of healthcare and pharmaceuticals.