EVALUATION THE CYTOTOXIC ACTIVITY SOME COMPOUNDS OF CLICK REACTION BETWEEN SUBSTITUTED (N-PROPARGYL)ISATINS AND 2,3,4,6 TETRA-O-ACETYL- β-D-GLUCOPYRANOSYL AZIDE

Abstract

Some 1,2,3-triazole compounds have been synthesized by click reaction between substituted (N
propargyl)isatins and 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl azide using CuI catalyst in t-BuOH as
solvent. The in vitro cytotoxic activity of some 1,2,3-triazole-isatin hybrid compounds was evaluated against
two cell lines of KB carcinoma (CCL-17TM) and HepG2 (HB-8065TM). The results showed that, 05
compounds had showed the ability to inhibit KB and HepG2 cancer cell lines with IC50 values = 83.20 -
91.84 and 29.5 - 86.86, respectively.