SYNTHESIS OF 5-FORMYL-2,4-DIMETHYL-1H-PYRROLE-3- CARBOXYLIC ACID USED IN PREPARATION OF SUNITINIB

Abstract

    A short and convenient synthesis of 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylicacid - an intermediate in preparation of anticancer drug Sunitinib have beenreported. By using a cheap, ready available starting material, a key intermediate insynthesis of Sunitinib was prepared by simple sequence reaction with high overallyield without purification by column.

Keyword(s): anticancer, sunitinib,Paal-Knor reaction