SYNTHESIS OF CITRIC ACID COATED Ag-CoFe2O4 NANOMATERIAL FOR APPLICATION IN BIOMEDICAL FIELD

Abstract

In this study, we focus on the synthesis of citric acid (AC) coated silver-cobalt ferrite nanoparticles (AC
coated CFO.Agx NPs, note as CAx NPs) by hydrothermal method combined mechanochemical ligand
exchange process. The structure, morphology and magnetic properties of CAx NPs were characterized
by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy
(TEM), and vibrating sample magnetometer (VSM). The solubility and stability of some CAx NPs
solution have been investigated, aqueous solution of 1 mg/mL CA0.2 are stable in neutral medium for
up to one month. CAx NPs were evaluated the antibacterial ability by disc diffusion test (Kirby-Bauer
method) against Gram-negative Pseudomonas aeruginosa (PA) and Gram-positive Staphylococcus
aureus (SA) bacterial in vitro. At the same concentration of 0.25 mg/mL, the antibacterial activity of
samples depended on the ratio of Ag doping: The zone of inhibition diameter for SA and PA increased
as the Ag content gradually increased from x = 0.05 to 0.2 and decreased slightly as further increased
pass to 0.2. The largest zone of inhibition diameter for SA and PA of CA0.2 NPs are 32 and 36 mm,
respectively. The hyperthermia studies showed that the CA0.2 NPs was highly suitable for magnetic
hyperthermia applications