NGHIÊN CỨU PHƯƠNG PHÁP PHÂN TÍCH TOLUEN TRONG NƯỚC TIỂU BẰNG PHƯƠNG PHÁP SẮC KÝ KHÍ KHỐI PHỔ KẾT HỢP VỚI KỸ THUẬT KHÔNG GIAN HƠI (HS-GC-MS/MS)

Tóm tắt

Urinalysis of toluene is important to monitor workers occupationally exposed to toluene as well as in the
diagnosis of some diseases related to chronic human exposure. Studies were carried out to establish the best
extraction conditions for the method, taking into account the various factors that affect the technique, such
as heating time, heating temperature, and the effect of salt addition. This work shows a sensitive, simple,
and rapid static headspace-gas chromatographic procedure for the quantitative determination of toluene in
urine. The limit of detection for toluene is 0.029 µg/L, with a standard deviation of less than 6%. Precisions
(%RSD) for toluene at different levels were less than 21%. Recoveries for toluene ranged from 80 to 110%.
Determination of Toluene in Urine using Headspace/Gas-Chromatography- Mass Spectrometry has the
sensitivity, repeatability, and recovery requirements of AOAC.