STUDY ON FABRICATION OF POLYCAPROLACTONE/XANTHAN GUM COMPOSITE FILMS LOADING CHRYSOPHANOL BY 3D PRINTING METHOD

Abstract

This paper presented the results of study on fabrication of polycaprolactone (PCL)/xanthan gum (XG)
composite films loading chrysophanol (CHR) by the 3D printing method with the ratio of PCL/XG of 85/15
and the content of CHR of 5 wt.%. The PCL and CHR were dissolved in dichloromethane (DCM) while the
XG was dissolved in distilled water. To mix the oil phase with water phase, the emulsifiers including
polyethylene oxide (PEO) and polysorbate 80 (Tween 80) were added with mass ratios of 15% and 5%,
respectively. The PCL/XG/CHR/emulsifier emulsion was used for 3D printing under different conditions,
consisting of printing speed, wet printing layer thickness, number of printing layers, and printing bed
temperature. The characteristics of obtained PCL/XG/CHR/emulsifier films were assessed through sample
moisture, dried sample thickness, Fourier transform infrared spectroscopy (FT-IR), stereomicroscopy,
scanning electron microscopy (SEM). In addition, the CHR content release studies at pH 2.0 and pH 7.4
buffer solutions (simulating the pH of human gastric and intestinal fluids) were carried out to find the most
suitable printing technologies for preparing PCL/XG/CHR/emulsifier films for medicine applications