Research on developing a formula for preparing floating tablet of acyclovir 100 mg

Abstract

     Acyclovir is an antiviral drug used in the treatment of infections mainly caused by Herpes simplex and Varicella Zoster viruses. However, when taken orally, the drug has low bioavailability (10 - 20)%. The reason acyclovir has low bioavailability is because the drug is mainly absorbed at the end of the stomach and the beginning of the small intestine, so for optimal absorption, the drug must be kept in the stomach. In order to improve treatment effectiveness and increase bioavailability of the drug, the research team has developed a formula for preparing acyclovir 100 mg floating tablets. The study investigated the influence of extended-release excipients (sodium croscarmelose (NaCMC), carbopol, sodium alginate, xanthan gum) and filler excipients on the quality parameters of semi-finished granules and tablets. compressed. The results were tablets prepared according to formula CT12 with ingredients: acyclovir 100 mg and excipients NaCMC (50 mg), carbopol (50 mg), lactose (40 mg), Avicel PH 101 (40 mg), polyvinyl pirrolidone K30 (PVP K30) (20 mg), sodium bicarbonate (100 mg) and magnesium stearate: talc 2% (ratio 1:1) have met the criteria of mass uniformity, hardness, abrasion, and durability. Drug content according to DĐVN V standards, ability to float for over 8 hours and sustained release up to 8 hours (94.90 %).