HYDROGEL COMPOSITE BASED BIPHASIC CALCIUM PHOSPHATE AND GELATIN, OXIDIZED ALGINATE FOR BONE REGENERATION

Abstract

Hydrogel composites based on oxidized alginate-gelatin and biphasic calcium phosphate (BCP) were implanted into rabbit femur. Evaluation of bone development after implantation into rabbit bones based on the results of micro-CT and histological analysis. Micro-CT data showed that hydrogel composites have bone surface/volume ratio and bone surface density higher than hydrogel. Hematoxylin-Eosin (H&E) staining technique for examination of bone structure, evaluation of cell growth in bone grafts showed that after 4 months and 6 months new bone formation, bone cells and blood vessels develop.

Keywords: Biphasic calcium phosphate, micro-CT, H&E, oxidized alginate, gelatin