PREPARATION OF CELLULOSE COATED HYDROGELS FOR CONTROLLED DRUG RELEASE

Abstract

In an attempt to improve material properties used for oral administration, which is
restricted by fast dissolution in the stomach, chitosan hydrogels were coated with cellulose dissolved in ionic liquid. Using insulin as a model compound, the properties of these cellulose-coated microparticles for the controlled release of drug were investigated. The results showed that the coated microparticles were more stable than those which were uncoated at low pH and suitable for oral delivery without requiring any harmful and sophisticated cross-linkage treatment.

Keywords: Chitosan, hydrogels, cellulose, drug release