Semi-chronic toxicity assessment of Phellinus linteus biomass powder from submerged-culture

Abstract

Phellinus linteus biomass powder obtained after submerge-fermentation was assested for semi-chronic toxicity in rabbit for evaluation of the safety of using it as functional food. Rabbits were drunk test solution continuously in 28 days with 2 doses: 0.558 g/kg rabbit/ day  and 2.792 g/kg rabbit/day. The result showed that the tested samples did not affect to weight, status, activity of tested  rabbit.  The biochemical index which expressed the liver, kidney functions had no statistical different at before test, after 14 days of test, after 28 days of test, and after 14 days finish of test between tested group and control group (without drink tested sample). The similarity results was obtained with hematological index. There were no abnormal occur in heart, liver, kidney, lung, spleen, and digestive system of tested rabbits in general observation as well as no histopathological lesions of the liver and kidneys in microscopic observation of tested group.