The effect of Phyllanthus amarus syrup in improving liver enzyme (ALT, AST levels) in dogs

Abstract

In Viet Nam, Phyllanthus amarus is commonly used as a herbal medicine to treat the liver diseases in human. However, the use of this herb medicine in veterinary, especially for small animals is not popular. This study was carried at a veterinary hospital in Ho Chi Minh City to determine the effect of
syrup product extracting from P. amarus to ALT and AST, biochemical parameters of the liver function in dogs. A total of 30 dogs from different breeds, including both male and female dogs were randomly selected and brought to the veterinary hospital for treatment. These dogs presented the abnormal parameters relating to the liver function. The clinical symptoms, biochemical analysis (ALT, AST) were performed, recorded for all the experimental dogs before treatment, then they were administered with
a dose of 1ml P. amarus syrup/kgBW/day, 30 minutes before meals for a duration of 2-3 weeks. The studied results showed that the clinical symptoms, such as fever, anorexia, in-appetence, weakness, fatigue, vomiting and diarrhea were mostly disappeared after 2-3 weeks of treatment. 100% of dog
used the syrup having the ALT and AST parameters gradually returned to normal range. The rate of dog recovering normal ALT, AST levels after 2 weeks of treatment was 41% (12/29) and 37% (7/19), respectively. After 3 weeks of treatment, the ALT levels of 83% (25/29) dogs returned to normal range
and the AST levels of 73% (14/19) dogs returned to normal range. The result of this study proved that Phyllanthus amarus syrup can be used t