Property of safety and immunity of attenuated African swine fever virus, strain G-delta-I177L for pigs

Abstract

The study was carried out with the aims to test safety and immunity of the attenuated ASFV
strain G-delta-I177L. The studied results showed that ASFV strain G-delta-I177L belonged to
genotype II, possessed ability to multiply well on the PBMC and BMC cells.
ASFV strain G-delta-I177L was safe to inject to pigs even when using high dose of 106 HAD50,
104 times higher than that of minimum immunizing dose (102 HAD50) to protect 100% pigs. By challenge experiments demonstrated that the pigs that injected with ASFV strain G-deltaI177L could stimulate immune response and be able to protect pigs against the virulent ASFV
causing ASF in pigs in Viet Nam. This proves that ASFV strain G-delta-I177L has matching
protective antigens to the virulent ASFV circulating in Viet Nam. From the studied results
obtained, it is suggested that ASFV strain G-delta-I177L can be used to product ASF vaccine
against ASF for pigs raising in Viet Nam