Study on some characteristics of the protein coding gene region of porcine parvovirus causing fetal mummification in pigs in Viet Nam

Abstract

Fetal mummification associated with porcine parvovirus (PPV) infection is one of the reproductive disorders in pigs that is always of interest to the pig farmers. Although, this disease has appeared in Viet Nam for a long time, to date there have been relatively few studies on the disease and circulation of this virus. This study was conducted to contribute to clarifying the basic molecular biology of the isolated virus strain PPV.DN.001. Of the 4,752 decoded nucleotides, strain PPV. DN.001 carried characteristics of the parvovirus group, had capability of independent replication with a %GC rate of 37.2%, and did not have a CpG-rich region. The virus encoding 4 non-structural proteins and 2 structural proteins, with typical arrangement carried the characteristics of viruses belonging to the protoparvovirus genus. The VP1 capsid protein of PPV.DN.001 carried all the typical functional domains of PPV. Among 6 genetic groups of PPV, strain PPV.DN.001 belonged to group C and differed with the attenuated PPV strain (NADL2) at 7 positions on the capsid protein.