Discordance rate between cervical cytology results and HPV DNA testing and related factors among women undergoing cervical biopsy at Hung Vuong Hospital

Tóm tắt

   Background: Cervical cancer screening strategies recommend HPV DNA testing as the primary screening method instead of PAP cytology test. However, PAP testing remains widely used, and public awareness of HPV infection remains low. According to global studies, CIN 2+ detection in PAP-negative, HPV 16/18-positive women ranges from 15% - 30%. This study aims to improve healthcare professionals’ screening practices in line with national guidelines.
   Objectives: To assess precancerous and cancerous lesions in discordant PAP-HPV cases and identify factors associated with discrepancies between PAP and HPV test results.
   Methods: A retrospective cross-sectional study was conducted on 905 women who underwent cervical cancer screening with PAP testing and HPV DNA testing and had abnormal cervical biopsy results at Hung Vuong Hospital.
   Results: The discordance rate between PAP and HPV was 52.4%, including PAP (-) HPV (+) 46.7% and PAP (+) HPV (-) 5.6%. Three factors were identified as significantly associated with PAP-HPV discordance in women with precancerous cervical lesions: Cervical evaluation, Vaginal inflammation and Histopathological severity of cervical lesions.
   Conclusion: HPV DNA testing should be adopted as the primary screening method per national guidelines.

DOI: 10.59715/pntjmp.5.2.6