SURVEY ON COAGULATION DISORDERS IN PATIENTS WITH SEPSIS ACCORDING TO THE SIC SCORE

Abstract

To determine the prevalence of coagulopathy in sepsis patients, clinical indicators according to the SOFA score, and laboratory indicators based on the SIC score at Thong Nhat Hospital. To investigate the correlation between the SIC score and disseminated intravascular coagulation (DIC). A cross-sectional descriptive study of sepsis patients aged 18 and older at Thong Nhat Hospital based on the Sepsis-3 criteria from November 2023 to July 2024. Among 106 sepsis patients, 69 (65.1%) were male, with an average age of 69.9 ± 17.1 years. The majority had hypertension (41.5%) and diabetes (26.4%), with infection sources primarily from the respiratory system (44.3%) and gastrointestinal tract (21.7%). The median SOFA score and SOFA (SIC score) were 5 (3 – 7) and 3 (2 – 5), respectively. Multiorgan dysfunction syndrome (MODS) was present in 54.7% of patients. The prevalence of coagulopathy in sepsis patients according to the SIC score was 49.1%. There was a statistically significant difference in the rate of coagulopathy between the multiorgan dysfunction syndrome group, those with thrombocytopenia < 150 G/L; INR > 1.2; aPTT > 37s; D-Dimer > 500ng/ml; total bilirubin > 21µmol/L; Hb < 10.5g/dL (p < 0.05). A positive correlation of r = 0.6 was found between the SIC score and the Overt-DIC score, significant with p < 0.05. Most sepsis patients are elderly with comorbidities. The rate of coagulopathy due to sepsis according to the SIC score is high and correlates with laboratory indicators such as thrombocytopenia, INR, aPTT, D-Dimer, total bilirubin, and Hb. There is a strong positive correlation with the DIC score.