ANTIDIABETIC AND ANTICANCER ACTIVITIES OF SOME COUMARIN-PYRIMIDINE HYBRID COMPOUNDS

Abstract

A series coumarin-pyrimidine hybrid compounds were synthesized by condensation reaction of α,βunsaturated ketone of 6-acetyl-5-hydroxy-4-methylcoumarin with guanidine. The yields of obtained
hybrid compounds were about 42-62%. Their antidiabetic and anticancer activities were scanned by
the standard methods. These compounds exhibited low toxicity to two cancer cell lines KB and HepG2,
but have remarkably inhibitory activity against diabetes enzymes. All synthesized hybrid compounds
were examined for in vitro α-amylase (with IC50 values in the range of 102.32 ± 1.15 μM to 249.52 ±
1.14 μM) and α- glucosidase (with IC50 values in the range of 52.16 ± 1.12 μM to 184.52 ± 1.15 μM)
inhibitory activity.