THE USE OF UV-VIS SPECTROSCOPY IN EVALUATION OF 5-FLUOROURACILACTIVE LOADING CAPABILITY OF IRON (III) –PEG MATERIA

Abstract

Fluorouracil (5-FU) adsorb the UV-Vis spectrosopy in the near ultraviolet wavelength region ( =
200÷400 nm). Therefore, the concentration of 5-FU in several different solution is able to determine by
UV-Vis spectroscopy. In this paper, UV-Vis spectroscopy was used in order to evaluate 5-FU loading
and unloading capability of Fe(III)-PEG250 material. The result indicated that 5-FU loaded capacity
was 14.275 mg/g and unloading time period was almost completed in 96 hours with an efficiency of
95.4%.