Development of a process for the simultaneous analysis of aceclofenac and diclofenac in tablet drug by uv spectrophotometric and its application in the estimation of the useful life of aceclofenac tablets

Abstract

Aceclofenac is an active ingredient widely used as anti-inflammatory and analgesic. However, during storage, a portion of aceclofenac is degraded and converted into diclofenac. This requires the needs for an accurate and simple analytical procedure to identify the two active substances. This paper presents the findings of a process development for the simultaneous analysis of aceclofenac and diclofenac by UV spectrophotometric. Based on such results, we investigated the kinetics of the degradation of aceclofenac and from that, estimated the useful life of aceclofenac tablets under certain storage conditions.

Keywords: Aceclofenac, Diclofenac, UV, Degradaion.