ASSESSMENT OF HERBAL MEDICINES FOR ANTI - LEUKEMIA EFFICACY

Abstract

In this research, we're looking for medicinal plants in Vietnam that have anti-cancer activity. Based on information synthesis from previous studies, we've compiled a list of 17 different medicinal plant species. Afterwards, extract and collect the crude extracts from these 17 plants and conduct further research on their ability to inhibit the proliferation of TCCY leukemia cell using the trypan blue staining technique. When compared to the control group (100%), the screening results indicated that the extracts had distinct effects on the TCCY cell line tested. The effects of Artemisia vulgaris extract (14,93 ± 1,58%) and Sphagneticola trilobata extract (30,55 ± 2,35%) on the proliferation of TCCY cells were significantly inhibited when compared to the control group (P< 0.0001). At a concentration of 100 µg/ml, Dialium cochinchinensis extract (P = 0.65) and Lonicera japonica extract (P = 0.02) exhibited no cytotoxicity toward TCCY cells. The remaining herbal extracts were found to be cytotoxic to cells at concentrations ranging from 52 to 87% of the tested cells.