Research to build basic standards for Atractylis herbal medicine

Abstract

This topic is a part of the State-level project with Code: 10/2017/ HĐ-NVQG dated on October 20, 2017: “Research, exploitation and development of Atractylis gene resources (Atractylodes macrocephala Koidz.) and Bo Chinh ginseng (Abelmoschus sagittifolius (Kurz) Merr.) as raw materials for drug production in Dak Lak and some provinces in Tay Nguyen". The objective of the topic is to study and develop basic standards for atractylis herbal medicine. Atractylis, scientific name Atractylodes macrocephala Koidz, is herbaceous, perennial, 40-60 cm high. Atractylis root is used medicinally. The research has established the TCCS for atractylis herbal medicine with the criteria keeping the same DVVN V: Description, microsurgery, powder characteristics, moisture, total ash, extractable substances, qualitative by thin layer chromatography method; The criteria to keep the Hong Kong DĐVN unchanged: ash insoluble in acid; Indicators changed and supplemented: Fingerprints; Adding indicators of 04 heavy metals (As, Pb, Cd, Hg), Residues of pesticides: Benzene hexachloride (BHC). Quantitative criteria of atractylenolide III (HPLC) specify atractylenolide III content ≥ 0.019 %. The quantitative method was validated according to the ICH guidelines.