Factors Influencing the Synthesis Process of 2-Methyl-5-Nitroimidazole

Abstract

The precursor 2-Methyl-5-nitroimidazole is used to synthesize the antibiotic Metronidazole used to treat bacterial infections. The process of synthesizing 2-Methyl-5-nitroimidazole gave the optimal parameters for the nitrification reaction of 2-methyl-1H-imidazole to produce 2-methyl-5-nitroimidazole products as follows: The molar ratio of 2-methyl-1H-imidazole to the volume of HNO₃ acid is 1mol / 125ml; The reaction temperature is 140 – 150^oC; The pH of the reaction medium is 5 – 6; The efficiency is 98%. The crystals are pale yellow and have a melting point at 250 – 252^oC; This article is the result of research on synthesis of 2-Methyl-5-nitroimidazole precursor and factors affecting the synthesis. The research results are the scientific basis for application to the production technology process, contributing to solving the problem of self-reliance in pharmaceutical raw materials in Vietnam