CLINICAL FEATURES AND RELATED FACTORS IN PATIENTS WITH CUTANEOUS SQUAMOUS CELL CARCINOMA.

Abstract

                      The objective of the study is to investigate clinical features and histopathological findings of patients with cutaneous squamous cell carcinoma (SCC) at National Hospital of Dermatology and Verenology (NHDV). The study’s method is the restrospective and spective descriptive study on data of 162 patients with cutaneous SCC at NHDV. Results show that, the number of patients with SCC has yearly increased from 2007 to 2014 at the NHDV. The most common age group of patients with SCC is the over 60 year-old group (69.65%). Farmers account for 60% of patients. SCC arised from chronic cutaneous eryptions makes up 39.85%. Lesions have often dominated on the exposed skin areas, including head and neck (52.74%). Ulcerated lesions are usually infiltrated rather than non-infiltrated (70.5% compared to 29.5%); 5 out of 18 patients (27.8%) have local lymph node metastasis. The tumour evoluting on chronic lesion has 1.56 times higher risk of lymph node metastasis than that developing on normal skin [95% CI; (1.05; 2.39)]. The infiltrated lesion has 1.63 times higher risk of lymph node metastasis compared to non-infiltrated tumours [95% CI; (1.06; 2.5)]. In conclusion, SCC has usually occurred in groups of people working under the sun and often appeared on previousskin lesions. The rate of lymph node metastasis is relatively high, and there has been a link between lymph node metastasis and previous skin lesions under the patterns of infiltration.