RESEARCH ON EXTENDED-RELEASE FELODIPIN AND GLIPIZID PREPARATION BY OSMOTIC PUMP MECHANISM.

Abstract

                      Extended-release systems by osmotic pump mechanism is a new field in Vietnam. Felodipine and Glipizid are in clinical use; however, thei poor solubility in water and short half-life lead to low efficiency treatment. Push-pull osmotic pump is the optimal choice for the preparation of extended-release form of these drugs in order to increase the bioavailability, treatment efficacy and technological development

of domestic pharmaceutical production. The Felodipine SR 5 mg and Glipizid SR 5 mg which could sustain the drug release from push-pull osmotic pump have been prepared. The batch of 10,000 coating tablets has been fully evaluated the stages of preparation. The specifications of the products have been developed, and the invitro bioavailability has also been evaluated. The study results have shown that the products are equivalent in quality to the trademark references on the market.