The relationship between serum pepsinogen and atrophic gastritis according to Olga classification

https://doi.org/10.52322/jocmbmh.120.03

Abstract

Objectives: This study aimed to evaluate the association of the serum pepsinogen and the atrophic gastritis stage according to the OLGA classification.

Material and Methods: A cross-sectional study was conducted with 95 patients at the age from 40 in the Department of Gastroenterology of Bach Mai hospital from March to December 2019. All patients were histopathologically diagnosed with atrophic gastritis according to OLGA classification. The level of serum pepsinogen I, pepsinogen II and Helicobacter pylori (H.P) antibody were measured.

Results: The mean level of PGI decreased significantly from stage I (74.2 ± 25.8 ng/ml),  stage II (53.1 ± 9.7 ng/ml) to stage III-IV (26.6 ± 8.5 ng/ml) (P < 0.05). The PG I/II ratios were significantly different between stage I (6.1 ± 1.9), stage II (5.3 ± 1.5), and stage III-IV (4.1 ± 0.8) (p < 0.05).  The significantly negative correlations were found between the level of PGI or PGI/II ratio and the severity of atrophic gastritis (r = - 0.539 and r = - 0.308, P < 0.05). The cut off value with PGI < 70 ng/ml and PGI/II < 3 could not be able to distinguish between severe atrophic gastritis (stage III-IV) and mild atrophic gastritis (stage I-II) (P = 0.536; 95% CI: 0.12 – 62.2).

Conclusion: There were significantly negative correlations between PGI or PGI/PGII ratio and the OLGA gastritis stage. The cut off value of Japan with PGI < 70 ng/ml and PGI/II ratio <3 could not find patients with atrophic gastritis stage III - IV.